What is Procaine PowderProcaine is a local anesthetic, and its hydrochloride is called novocaine. With its hydrochloride, it is white crystalline or crystalline powder. It is odorless and slightly bitter. A sense of paralysis follows. It is soluable in water. The duration of procaine’s local anesthesia is about 1 hour. If a trace of adrenaline is added to the drug solution, the effect can last for 1 ~ 2 hours. It has weak penetration to skin and mucous membrane, and it is not suitable for topical anesthesia. After absorption, the product is mainly hydrolyzed into p-aminobenzoic acid and diethylaminoethanol by plasma pseudocholinesterase. The former can competitively resist the antibacterial effect of sulfonamides and weaken the curative effect of sulfonamides; the latter can enhance the effect of digitalis. Patients who have used enough digitalis shall use this drug with caution. If procaine is combined with succinylcholine, both drugs are hydrolyzed by plasma pseudocholinesterase. When a large amount of procaine is injected intravenously, it may compete with hydrolase to reduce the hydrolysis and inactivation of succinylcholine, significantly strengthen and prolong its muscle relaxation, result in respiratory muscle paralysis. If a large amount of procaine is absorbed, it will stimulate the central nervous system, and then turn to inhibition, which is manifested as restlessness, convulsion, coma and respiratory paralysis. A few patients have allergic reactions.
DOWNLOAD CHEMICAL MARKET INSIGHTS REPORT