Local Anesthesia API Supplier – Benzocaine Powder | Procaine Powder | Lidocaine Powder
What is Lidocaine Powder
Lidocaine exerts the effect of local anesthesia by reversibly blocking the sodium channel and blocking the transmission of action potential on nerve fibers. Sensory nerve fibers are blocked earlier than motor nerve fibers, so low-dose lidocaine can exert selective sensory blockade. Lidocaine also has antiarrhythmic effect and it belongs to class Ib antiarrhythmic drugs. It can reduce ventricular rate, shorten action potential time and absolute refractory period, and prolong relative refractory period. Lidocaine takes effect fast and it has short duration. The addition of adrenaline to lidocaine can reduce the rate of systemic absorption and prolong the anesthesia time.
Lidocaine Powder Effects
Lidocaine is applicable for acute ventricular arrhythmias caused by acute myocardial infarction, surgery, digitalis poisoning and cardiac catheters, including ventricular premature beats, ventricular tachycardia and ventricular fibrillation. Secondly, it is also used for status epilepticus.LIDOCAINE POWDER
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FAQ
Lidocaine Powder Uses
Lidocaine is a common drug for the treatment of ventricular arrhythmias caused by acute and severe hemodynamic abnormalities. It is also effective for some supraventricular arrhythmias, such as bypass mediated supraventricular tachycardia and acute or parasympathetic mediated atrial fibrillation. It is widely used for mucosal topical anesthesia (such as before endotracheal intubation). EMLA cream is used for skin topical anesthesia before intravenous intubation. In order to guarantee the anesthetic effect, it is necessary to apply it on the skin for 45 ~ 60min, and wrap it with airtight dressing to promote absorption. EMLA is very useful for rabbit ear vein intubation and young dog and cat intravenous intubation.What is Lidocaine Powder Used For
Lidocaine is a local anesthetic, and it is also known as xylocaine. In recent years, lidocaine has replaced procaine and it is widely used in local infiltration anesthesia in cosmetic and plastic surgery. It blocks nerve excitation and conduction by inhibiting the sodium channel of nerve cell membrane. Its fat solubility and protein binding rate are higher than those of procaine. It has strong cell penetrating ability and long action time, takes effect fast and its action intensity is 4 times that of procaine. It is clinically used in infiltration anesthesia, epidural anesthesia, topical anesthesia (including mucosal anesthesia during thoracoscopy or abdominal surgery) and nerve conduction blockage. In order to prolong the anesthesia time and reduce the adverse effects such as lidocaine poisoning, adrenaline can be added to the anesthetics. Lidocaine can also be used to treat ventricular premature beats, ventricular tachycardia after acute myocardial infarction, digitalis poisoning, ventricular arrhythmias caused by cardiac surgery and cardiac catheters, including ventricular premature beats, ventricular tachycardia and ventricular fibrillation. Secondly, it is also used for patients with status epilepticus who are ineffective with other anticonvulsants and local or intraspinal anesthesia, but it is usually ineffective for supraventricular arrhythmia.
chemical property
White acicular crystal. Its melting point is 68-69 ℃ and boiling point is 180-182 ℃ (0.53kPa). It is soluble in ethanol, ether, benzene, trichloromethane and oil at 159-160 ℃ (0.267kPa). It is insoluble in water. Lidocaine hydrochloride (C14H22N2O ·HCl, [73-78-9]) is white crystalline powder. Its melting point is 127-129 ℃, and the melting point of monohydrate is 77-78 ℃. It is very soluble in water, 0.5% aqueous solution pHO4.0-5.5. It is orderless and it has bitter taste.
How to Use Lidocaine Powder
Lidocaine can be considered a very good local anesthetic. Generally, it can take effect in 1-3 minutes. The curative effect will last for 1 to 3 hours. It is mainly used to treat oral ulcer and it can also be used as a drug for arrhythmia. But now it is not used very much, because people are worried about the adverse effects of this drug for a long time. Moreover, many people will have obvious allergies after using lidocaine, but as early as 1963, the effect of this drug on arrhythmia was relatively good. Lidocaine can be used for some types of diseases such as acute myocardial infarction or tachycardia.What is the Lidocaine Powder Used For
The drug is an amide local anesthetic. It is widely used in topical anesthesia, infiltration anesthesia, conduction anesthesia and epidural anesthesia. The oral LD50 of lidocaine hydrochloride in mice is 290mg/kg. It is used as a local anesthetic.
Production method
It is obtained by acylation and amination of 2,6-dimethylaniline.1. Acylation Dissolve 2,6-dimethylaniline in anhydrous benzene, cool it to below 28 ℃, stir and slowly add chloroacetyl chloride, and control the temperature below 30 ℃. After addition, stir it for reaction for 1h, and then heat and reflux it for 8h. [(2,6-dimethylphenyl)aminocarbonylmethyl]chloride is obtained by cooling, crystallization, filtration and drying. The yield is 75%. 2. Amination Add the above [(2,6-dimethylphenyl)aminocarbonylmethyl]chloride to benzene, then add diethylamine, stir, heat and reflux it for 7h. After most of the benzene is recovered, cool and crystallize it, and filter and wash it with benzene. Merge the benzene solution, extract with 10% hydrochloric acid, decolorize the extract with activated carbon and filter it. Adjust the pH of the filtrate to 10 with 10% sodium hydroxide solution, precipitate and crystallize, filter, wash it with water to neutral, and obtain lidocaine. After recrystallization, lidocaine hydrochloride is formed with hydrochloric acid. The yield of amination is 76%.