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What is Benzocaine Powder

Benzocaine’s chemical name is ethyl p-aminobenzoate and its chemical formula is C9H11NO2. It is an organic compound. It is colorless oblique crystal, and it is odorless. It is soluble in alcohol, ether and trichloromethane, almond oil, olive oil, dilute acid and it is insoluble in water. Clinically, the benzocaine powder is used to relieve pain and itch in wounds, ulcers, burns, skin cracks and hemorrhoids. From the appearance, two types of benzocaine powder are available, which are 40-mesh and 200-mesh benzocaine. Their purity and quality are strictly controlled. Usually, when customers do not have strict require.
Benzocaine Powder

Basic information of benzocaine powder

Benzocaine Powder
CAS : 94-09-7
EINECS No.: 202-303-5
MF : C9H11NO2
Megawatt: 166.1965
Melting point: 89 ℃ to 90.5 ℃
Boiling point: 310.7℃ , 760 mmHg
Flash point: 164.2℃
Steam pressure: 0.000589mmHg at 25 ℃
Mp : 89-92℃
Benzocaine powder usage: it is used for ultraviolet absorption of cosmetics, local anesthetics, wounds, ulcer pain and hemorrhoids.

40-mesh benzocaine powder
Because benzocaine is a type of crystalline powder, i.e. 40-mesh benzocaine powder, some people tend to call it crystalline benzocaine powder, fluffy benzocaine. 40-mesh benzocaine bought from China is very popular. Some customers will state that they merely want to buy 40 mesh. Some customers even express dissatisfaction because some crystal powder changes into powder under high pressure. Therefore, we can change the packaging of 25 kg/barrel benzocaine powder to 5 kg/bag to avoid this problem.

200-mesh benzocaine powder
200-mesh benzocaine powder which is further processed from 40 mesh belongs to a higher grade. We offer benzocaine, but customers who use benzocaine can buy products containing benzocaine in the market, usually benzocaine cream, benzocaine gel, benzocaine delayed condoms and benzocaine spray.
Therefore, 200-mesh benzocaine has better dissolution rate and efficiency, which is popular among manufacturers.


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    How to Use Benzocaine Powder

    Benzocaine powder is used for cough medicine, ear drops, throat buccal tablet and even condoms. Why is benzocaine powder used in these products? At first, we should know that benzocaine powder is a liposoluble topical anesthetic. Compared with other local anesthetics such as lidocaine and dimethocaine, its action intensity is smaller, so it will not make people feel uncomfortable when it acts on the mucosa. It is a drug with strong fat solubility, so it is easy to be combined with the lipid layer of mucosa or skin, but it is not easy to penetrate into the human body and produce toxicity. 1.The benzocaine powder is used in benzocaine spray for temporary relief of pain and itching, skin discomfort, mild burns, sunburn, wounds and insect bites. 2. Benzocaine powder is used in ear preparation to relieve the pain and itching of acute congestive otitis externa, external centralized otitis and otitis externa. 3. Benzocaine powder is used as a product for oral ulcer because of its anesthetic, analgesic and pruritus effects on wound, ulcer, mucosal surface and hemorrhoids. 4. Benzocaine powder is also effective in the treatment of toothache, sore throat, oral ulcer, various hemorrhoids, anal cracks and vulvar pruritus. 5. Benzocaine powder is used in delayed condoms for premature ejaculation.

    What is Benzocaine Hydrochloride Powder

    Benzocaine hydrochloride powder is the hydrochloric acid form of benzocaine for local anesthesia. Benzocaine hydrochloride powder shares the same pharmacological effect with benzocaine, and its anesthetic effect is weaker than procaine. Its local absorption is slow and the effect is lasting. Because benzocaine hydrochloride powder is insoluble in water, it cannot be used as an infiltration anesthetic and it has analgesic and antipruritic effects. The drug is usually made into benzocaine hydrochloride powder or ointment, which is used to treat wounds, ulcer, burns, skin wear and hemorrhoids. Benzocaine hydrochloride powder CAS: 23239-88-5 EINECS No.: 233-216~0 MF : C9H12CINO2 Megawatt: 201.65000 boiling point: 495℃, 760mmHg flash point: 228.6℃ Steam pressure: 0.000589mmHg at 25℃ The effect of benzocaine hydrochloride powder is the same as that of benzocaine powder, but its production cost is higher than that of benzocaine powder. Therefore, most customers will choose benzocaine powder in the market.

    What is Benzocaine Powder Used For

    Benzocaine is white acicular crystal. Its chemical name is ethyl 4-aminobenzoate or ethyl p-aminobenzoate (CAS No.:94-09-7, molecular formula: C9H11NO2, molecular mass:165). Its melting point is 90-92℃. It is slightly soluble in water and easily soluble in organic solvents such as ethanol, trichloromethane and ether, and it is soluble in almond oil and olive oil. As a water-insoluble local anesthetic, benzocaine can relieve pain and itching. Clinically, it is used for wound anesthesia, ulcer surface anesthesia, mucosal topical anesthesia and hemorrhoid anesthesia. Its pharmacological effect is mainly to block the nerve ending to relieve pain and itching. The remarkable feature of benzocaine is that it is easy to be combined with the lipid layer on the mucous membrane or skin surface and it is not easy to enter the human body to produce toxicity. There are more than 100 types of benzocaine preparations abroad, including 27 types of tablets, 17 types of ointment, 6 types of cream, 3 types of capsules, and other preparations such as suppository, lotion, gel, aerosol, etc. It is mainly used for oral sterilization, oral ulcers and throat pain. Compared with foreign countries, benzocaine is only used to relieve itching in ointment in China, and the varieties of preparations need to be further developed. In addition, benzocaine is an important intermediate in organic synthesis. It is mainly used in the production of medicine, plastics and coatings. Benzocaine has anesthetic effect. On this basis, it can synthesize anesthetic drugs such as orthform, orthocaine and new orthform. Many excellent PABA local anesthetics have been synthesized, such as procaine and many analogues of procaine. These anesthetics are featured by good stability, rapid effect, long maintenance time and small adverse effects, so they are widely used.

    Benzocaine Powder Effects

    Temporarily relieve pain and discomfort of itchy skin, mild burns, sunburn, trauma and stings. Preparations for ears are used to mitigate the pain and itching of acute congestive, concentrated otitis externa and swimming otitis. It is also effective for toothache, throat pain, oral ulcer, various hemorrhoids, anal fissure and vulvar pruritus. It can be used as a desensitizer for male genitalia to slow ejaculation, or as an anesthetic lubricant for catheters and endoscopic tubes.

    Benzocaine Powder Uses

    usage and dosage: benzocaine powder uses
    5% – 10% ointment or fabric agent is used to relieve itching on local wounds, and suppository can be used for hemorrhoid pain.

    [pharmacological action and mechanism]
    Benzocaine has weaker local anesthetic effect than procaine, and it cannot be infiltrated, and its local absorption is slow and lasting. It can be hydrolyzed into p-aminobenzoic acid. It has no irritation and toxicity at the normal use concentration of 2% – 10%, and the toxicity is only equivalent to 5% or 10% of cocaine. The maximum safety dosage for local use is 5g or 25 ml 20% solution. It inhibits the conduction of nerve impulses from sensory nerve endings and dulls taste. Its structure is similar to that of procaine, so its absorption is slow and the anesthetic effect is lasting.

    Overview and preparation development of benzocaine Benzocaine is rarely absorbed through normal skin, but it is quickly absorbed through mucous membrane. It is metabolized by plasma choline esterase and less by liver choline esterase. This product is little absorbed when used locally, and it takes effect after topical anesthesia for 15 ~ 30 minutes. The 7.5% gel takes effect after it is partially applied for 7 minutes, lasting 12 to 15 minutes, and 10% or 20% gel continues for 3 to 5 hours. After absorption, the product is metabolized through the liver and excreted as prototype drug with a small amount through the kidney.

    It is recorded in the US Pharmacopoeia (24th Edition), the British Pharmacopoeia (1998 edition), the Chinese Pharmacopoeia (2000 EDITION) , etc. There are many types of powder, 5% ointment and suppository in China. There are more varieties abroad, which are used for oral sterilization, ulcers, throat pain and itching, and there are more varieties of buccal tablet, spray and ear preparations. See Table 1. The US Pharmacopoeia (24 Edition) also contains single compound gel, ointment, cream, surface solution, etc.

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